主要代表性论文
【1】Ying K,Qin W,Xu Y,Lv D,Zhu H,Li Y,Xu W,Yan C,Li Y,Cheng H,Chen E,Ma G,Zhang X,Ke Y.NanoSHP099-Targeted SHP2 Inhibition Boosts Ly6Clow Monocytes/Macrophages Differentiation to Accelerate Thrombolysis.Advanced Science,2024 accetped.
【2】Wu C，Zheng P,Ma L,Xu C,Hu L,Yang Z,Fei F,Shen Z,Zhang X,Wu Z,Cheng H,Mao W,Ke Y.Protein tyrsosine phosphatase Shp2 in marcophages acts as anti-atherosclerotic regulator in mice.Arterioscler Thromb Vasc Biol 2024 44(1)：202-17
【3】Li Y,Zhou H,Liu P,Lv D,Shi Y,Tang B,Xu J,Zhong T,Xu W,Zhang J,Zhou J,Ying K,Zhao Y,Sun Y,Jiang Z,Cheng H，Zhang X,Ke Y.SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47-SIRPαaxis.J Clin Invest.2023;133(4)：e162870.
【4】Xiao P,Hu Z，Lang J，Pan T，Mergers R，Zhang H,Guo K,Shen M,Cheng H，Zhang X,Cao Q,Ke Y.Mannose metabolism normalizes the gut homeostasis by preventing TNFalpha-mediated proinflammatory circuit.Cell Mol Immunol.2023(20),119–130
【5】Zhang Y,Li Y,Liu P,Gong D,Zhou H,Li W,Zhang H,Zheng W,Xu J，Cheng H,Zhang X，Ke Y.Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin.J Extracell Vesicles 2021 10.1002/jev2.12078.
【6】Xu Y,Zhang Y,Yang Y,Liu Y,Tian Q,Liu P,Ding Z,Cheng H,Zhang X,Ke Y.Tyrosine phosphatase Shp2 regulates p115RhoGEF/Rhodependent dendritic cell migration.Cell Mol Immunol.2021;18(3)：755-757
【7】Guo Y，Liu Y，Zhao S，Xu W，Li Y,Zhao P,Wang D,,Cheng H,Ke Y,Zhang X Oxidative stress-induced FABP5 S-glutathionylation against acute lung injury by suppressing inflammation in macrophages.Nature Communications 2021 12(1),1-18
【8】Xu Z，Guo C，Ye Q，Shi Y，Sun Y,Zhang J,Huang J,Huang Y,Zeng C,Zhang X,Ke Y,Cheng H.Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization.Nature Communications 2021 Nov 2;12(1)：6310
【9】Xiao P,Zhang H,Zhang Y,Zheng M,Liu R,Zhao Y,Zhang X,Cheng H,Cao Q,Ke Y.Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10.J Exp Med 2019 216(2)：337-49
【10】Xiao P,Guo Y,Zhang H,Zhang X,Cheng H,Cao Q,Ke Y.Myeloid-restricted ablation of Shp2 restrains melanoma growth by amplifying the reciprocal promotion of CXCL9 and IFN-γproduction in tumor microenvironment.Oncogene 2018 37(37)：5088-100
【11】Zhang Y,Xu Y,Liu S,Guo X,Cen D,Xu J,Li H,Li K,Zeng C,Lu L,Zhou Y,Shen H,Cheng H,Zhang X,Ke Y.Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma.Cell Research 2016 26：1226-41
【12】Ke Y,Zhang EE,Hagihara K,Wu D,Pang Y,Feng GS.Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.Mol Cell Biol.2007;27(19)：6706-17
【13】Ke Y,Su B,Song X,Lu D,Chen L,Li H,Qi C,Marzuki S,Deka R,Underhill P,Xiao C,Shriver M,Lell J,Wallace D,Wells RS,Seielstad M,Oefner P,Zhu D,Jin J,Huang W,Chakraborty R,Chen Z,Jin L.African origin of modern humans in East Asia：a tale of 12,000 Y chromosomes.Science.2001;292(5519)：1151-3.
【14】Ke Y,Su B,Li H,Chen Y,Qi C,Guo X,Huang W,Jin J,Lu D,Jin L*.Y-chromosome evidence for no independent origin of modern human in China.Chin Sci Bull 2001 46(11)：935-937中文版科学通报2001(5)411-414
【15】Ke Y,Su B,Xiao J,Chen H,Huang W,Chen Z,Chu J,Tan C,Jin L,Lu D*.The Y-SNP Polymorphism distribution in China and origin and migration of Chinese.Sci China C Life Sci.2001 44(3)：225-32.中文版中国科学2000(6)614-620
【1】Ying K,Qin W,Xu Y,Lv D,Zhu H,Li Y,Xu W,Yan C,Li Y,Cheng H,Chen E,Ma G,Zhang X,Ke Y.NanoSHP099-Targeted SHP2 Inhibition Boosts Ly6Clow Monocytes/Macrophages Differentiation to Accelerate Thrombolysis.Advanced Science,2024 accetped.
【2】Wu C，Zheng P,Ma L,Xu C,Hu L,Yang Z,Fei F,Shen Z,Zhang X,Wu Z,Cheng H,Mao W,Ke Y.Protein tyrsosine phosphatase Shp2 in marcophages acts as anti-atherosclerotic regulator in mice.Arterioscler Thromb Vasc Biol 2024 44(1)：202-17
【3】Li Y,Zhou H,Liu P,Lv D,Shi Y,Tang B,Xu J,Zhong T,Xu W,Zhang J,Zhou J,Ying K,Zhao Y,Sun Y,Jiang Z,Cheng H，Zhang X,Ke Y.SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47-SIRPαaxis.J Clin Invest.2023;133(4)：e162870.
【4】Xiao P,Hu Z，Lang J，Pan T，Mergers R，Zhang H,Guo K,Shen M,Cheng H，Zhang X,Cao Q,Ke Y.Mannose metabolism normalizes the gut homeostasis by preventing TNFalpha-mediated proinflammatory circuit.Cell Mol Immunol.2023(20),119–130
【5】Zhang Y,Li Y,Liu P,Gong D,Zhou H,Li W,Zhang H,Zheng W,Xu J，Cheng H,Zhang X，Ke Y.Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin.J Extracell Vesicles 2021 10.1002/jev2.12078.
【6】Xu Y,Zhang Y,Yang Y,Liu Y,Tian Q,Liu P,Ding Z,Cheng H,Zhang X,Ke Y.Tyrosine phosphatase Shp2 regulates p115RhoGEF/Rhodependent dendritic cell migration.Cell Mol Immunol.2021;18(3)：755-757
【7】Guo Y，Liu Y，Zhao S，Xu W，Li Y,Zhao P,Wang D,,Cheng H,Ke Y,Zhang X Oxidative stress-induced FABP5 S-glutathionylation against acute lung injury by suppressing inflammation in macrophages.Nature Communications 2021 12(1),1-18
【8】Xu Z，Guo C，Ye Q，Shi Y，Sun Y,Zhang J,Huang J,Huang Y,Zeng C,Zhang X,Ke Y,Cheng H.Endothelial deletion of SHP2 suppresses tumor angiogenesis and promotes vascular normalization.Nature Communications 2021 Nov 2;12(1)：6310
【9】Xiao P,Zhang H,Zhang Y,Zheng M,Liu R,Zhao Y,Zhang X,Cheng H,Cao Q,Ke Y.Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10.J Exp Med 2019 216(2)：337-49
【10】Xiao P,Guo Y,Zhang H,Zhang X,Cheng H,Cao Q,Ke Y.Myeloid-restricted ablation of Shp2 restrains melanoma growth by amplifying the reciprocal promotion of CXCL9 and IFN-γproduction in tumor microenvironment.Oncogene 2018 37(37)：5088-100
【11】Zhang Y,Xu Y,Liu S,Guo X,Cen D,Xu J,Li H,Li K,Zeng C,Lu L,Zhou Y,Shen H,Cheng H,Zhang X,Ke Y.Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma.Cell Research 2016 26：1226-41
【12】Ke Y,Zhang EE,Hagihara K,Wu D,Pang Y,Feng GS.Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.Mol Cell Biol.2007;27(19)：6706-17
【13】Ke Y,Su B,Song X,Lu D,Chen L,Li H,Qi C,Marzuki S,Deka R,Underhill P,Xiao C,Shriver M,Lell J,Wallace D,Wells RS,Seielstad M,Oefner P,Zhu D,Jin J,Huang W,Chakraborty R,Chen Z,Jin L.African origin of modern humans in East Asia：a tale of 12,000 Y chromosomes.Science.2001;292(5519)：1151-3.
【14】Ke Y,Su B,Li H,Chen Y,Qi C,Guo X,Huang W,Jin J,Lu D,Jin L*.Y-chromosome evidence for no independent origin of modern human in China.Chin Sci Bull 2001 46(11)：935-937中文版科学通报2001(5)411-414
【15】Ke Y,Su B,Xiao J,Chen H,Huang W,Chen Z,Chu J,Tan C,Jin L,Lu D*.The Y-SNP Polymorphism distribution in China and origin and migration of Chinese.Sci China C Life Sci.2001 44(3)：225-32.中文版中国科学2000(6)614-620
